Renewal of Life was introduced in the 2nd group of Trail of Painted Ponies in Summer of 2003. Renewal of Life retired in January 2007. The last numbered pony was #5E/120 which mean that 50,120 of this pony were made.

The travels of the artist, Natasha Isenhour, is the inspiration for this pony. A dawn seen through mists hovering over the Rio Grande that flows through a bird sanctuary in southern New Mexico inspired this work of art. Whether she is painting on a canvas or a Pony, this artist has a unique ability to create a spiritual luminescence that invites the viewer to enter a meditative space that seems to live inside her art.